DNA Immunization against Experimental Genital Herpes Simplex Virus Infection
نویسندگان
چکیده
منابع مشابه
DNA immunization against experimental genital herpes simplex virus infection.
A nucleic acid vaccine, expressing the gene encoding herpes simplex virus (HSV) type 2 glycoprotein D (gD2) under control of the cytomegalovirus immediate-early gene promoter, was used to immunize guinea pigs against genital HSV-2 infection. The vaccine elicited humoral immune responses comparable to those seen after HSV-2 infection. Immunized animals exhibited protection from primary genital H...
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Previously we reported the development of a plasmid DNA expression vector system derived from Sindbis virus (T. W. Dubensky, Jr., et al., J. Virol. 70:508-519, 1996). In vitro, such vectors exhibit high-level heterologous gene expression via self-amplifying cytoplasmic RNA replication. In the present study, we demonstrated the in vivo efficacy of the Sindbis virus-based pSIN vectors as DNA vacc...
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The association of genital herpetic infections with gonorrhoea and other venereal diseases has been noted since the latter part of the 19th century (Diday and Doyon, 1886). Recently, Beilby, Cameron, Catterall, and Davidson (1968) in England have suggested the possibility that gonorrhoeal infection may trigger recurrences of herpetic cervicitis. To test this hypothesis, the present study was co...
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Primary genital herpes simplex virus (HSV) infection is commonly associated with systemic symptoms. A systematic evaluation of HSV viremia during primary genital infection has not been performed previously. Plasma samples from adults with a first clinical episode of genital HSV infection were assayed for HSV DNA by polymerase chain reaction. One hundred sixty-four adults had confirmed primary g...
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ژورنال
عنوان ژورنال: Journal of Infectious Diseases
سال: 1996
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/173.4.800